Azepines are seven-membered heterocycles with one nitrogen atom. This class of heterocyclic compounds is important because this scaffold is found in the molecular skeleton of many pharmaceuticals, such as cetiedil and mecillinam and some natural products. Azepines and their partly or fully reduced congeners are found as constituents of the wide range of natural products and pharmaceutically important compounds or their precursors. It is worthy to note that the interest in seven-membered azaheterocycles from pharmacologists, synthetic chemists and theorists has persistently been increased due to not only variety of bioactivities, but also high reactivity and some unique properties of these compounds. Particular focus has been put on the synthesis of azepine derivatives, because these are important skeletal units that are found in numerous natural products and in compounds with important chemical, biological and medicinal properties. In the present article different methodologies for the synthesis of azepines are discussed.
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